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BS-400/BS-420 Chemistry Analyzer

Service Manual

© 2007-2008 Shenzhen Mindray Bio-medical Electronics Co., Ltd. All rights Reserved. For this Service Manual, the issued Date is 2008-07 (Version: 1.1).

Intellectual Property Statement SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (hereinafter called Mindray) owns the intellectual property rights to this Mindray product and this manual. This manual may refer to information protected by copyrights or patents and does not convey any license under the patent rights of Mindray, nor the rights of others. Mindray does not assume any liability arising out of any infringements of patents or other rights of third parties. Mindray intends to maintain the contents of this manual as confidential information. Disclosure of the information in this manual in any manner whatsoever without the written permission of Mindray is strictly forbidden. Release, amendment, reproduction, distribution, rent, adaption and translation of this manual in any manner whatsoever without the written permission of Mindray is strictly forbidden. , , , , are the registered trademarks or trademarks owned by Mindray in China and other countries. All other trademarks that appear in this manual are used only for editorial purposes without the intention of improperly using them. They are the property of their respective owners.

Responsibility on the Manufacturer Party Contents of this manual are subject to changes without prior notice. All information contained in this manual is believed to be correct. Mindray shall not be liable for errors contained herein nor for incidental or consequential damages in connection with the furnishing, performance, or use of this manual. Mindray is responsible for safety, reliability and performance of this product only in the condition that:

„ „ „

all installation operations, expansions, changes, modifications and repairs of this product are conducted by Mindray authorized personnel; the electrical installation of the relevant room complies with the applicable national and local requirements; the product is used in accordance with the instructions for use.

WARNING: It is important for the hospital or organization that employs this equipment to carry out a reasonable service/maintenance plan. Neglect of this may result in machine breakdown or injury of human health.

i

Warranty THIS WARRANTY IS EXCLUSIVE AND IS IN LIEU OF ALL OTHER WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE. Exemptions Mindray's obligation or liability under this warranty does not include any transportation or other charges or liability for direct, indirect or consequential damages or delay resulting from the improper use or application of the product or the use of parts or accessories not approved by Mindray or repairs by people other than Mindray authorized personnel. This warranty shall not extend to:

„ „ „

any Mindray product which has been subjected to misuse, negligence or accident; any Mindray product from which Mindray's original serial number tag or product identification markings have been altered or removed; any product of any other manufacturer.

Return Policy Return Procedure In the event that it becomes necessary to return this product or part of this product to Mindray, the following procedure should be followed: 1

Obtain return authorization: Contact the Mindray Service Department and obtain a Customer Service Authorization (Mindray) number. The Mindray number must appear on the outside of the shipping container. Returned shipments will not be accepted if the Mindray number is not clearly visible. Please provide the model number, serial number, and a brief description of the reason for return.

2

Freight policy: The customer is responsible for freight charges when this product is shipped to Mindray for service (this includes customs charges).

3

Return address: Please send the part(s) or equipment to the address offered by Customer Service department

Company Contact

ii

Manufacturer:

Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

Address:

Mindray Building, Keji 12th Road South, Hi-tech Industrial Park, Nanshan, ShenZhen518057, P.R.China

Tel:

+86 755 26582479 26582888

Fax:

+86 755 26582934 26582500

Foreword Who Should Read This Manual This manual is geared for service personnel authorized by Mindray.

What Can You Find in This Manual This manual covers principles, installation procedures, theories, maintenance and troubleshooting guidelines of the BS-400/BS-420. Please service the system strictly as instructed by this manual.

Conventions Used in This Manual This manual uses the following typographical conventions to clarify meanings in the text. Bold and Italic font indicates text displayed on the screen, such as Sample Request.

Safety Symbols This chart explains the symbols used in this manual. When you see…

Then…

WARNING

Read the statement following the symbol. The statement is alerting you to an operating hazard that can cause personal injury.

BIOHAZARD

Read the statement following the symbol. The statement is alerting you to a potentially biohazardous condition.

CAUTION

Read the statement following the symbol. The statement is alerting you to a possibility of system damage or unreliable results.

NOTE

Read the statement following the symbol. The statement is alerting you to information that requires your attention.

Labels Used On the System The labels attached to the panels of the system use symbols to clarify the meaning of the text. The chart below explains the symbols on the labels. Serial Number Date of Manufacture

Foreword

1

Manufacturer CE marking. The device is fully in conformity with the Council Directive Concerning In Vitro Diagnostic Medical Devices 98/79/EC. Authorized Representative in the European Community The following definition of the WEEE label applies to EU member states only: The use of this symbol indicates that this product should not be treated as household waste. By ensuring that this product is disposed of correctly, you will help prevent bringing potential negative consequences to the environment and human health. For more detailed information with regard to returning and recycling this product, please consult the distributor from whom you purchased the product. In Vitro diagnostic equipment Biohazard warning: risk of potentially biohazardous infection

Warning: Risk of personal injury or equipment damage

Warning: risk of burn

Caution: laser radiation Protective ground terminal

ON (Main Power) OFF (Main Power) ON (Power) OFF (Power) COM HIGH WASTE

2

Serial Port CONC.

High-concentration waste

HIGH CONC. WASTE SENSOR

High-concentration waste sensor

LOW CONC. WASTE 1

High-pressure low-concentration waste

Foreword

LOW CONC. WASTE 2

Normal-pressure low-concentration waste

DEIONIZED WATER

Deionized water

Model: BS-400/BS-420

Product model

Graphics All graphics, including screens and printout, are for illustration purposes only and must not be used for any other purpose.

EC Representative Name: Address: Phone: Fax:

Shanghai International Holding Corp. GmbH (Europe) Eiffestraβe 80, 20537 Hamburg Germany 0049-40-2513175 0049-40-255726

Foreword

3

Safety Precautions Observe the following safety precautions when using the BS-400/BS-420 Chemistry Analyzer. Ignoring any of these safety precautions may lead to personal injury or equipment damage.

WARNING If the system is used in a manner not specified by Mindray, the protection provided by the system may be impaired.

Preventing Electric Shock Please observe the following instructions to prevent electric shock.

WARNING When the Main Power is on, users must not open the rear cover or side cover. Spillage of reagent or sample on the analyzer may cause equipment failure and even electric shock. Do not place sample and reagent on the analyzer. In case of spillage, switch off the power immediately, remove the spillage.

Preventing Personal Injury Caused by Moving Parts Please observe the following instructions to prevent personal injury caused by moving parts.

WARNING Do not touch such moving parts as sample probe, reagent probe, mixer and wash probe, when the system is in operation. Do not touch the sample probe or mixer while the system is in operation. Make sure the reagent disk cover is properly installed.

Preventing Personal Injury Caused by Photometer Lamp Please observe the following instructions to prevent personal injury caused by photometer lamp.

WARNING Light sent by the photometer lamp may hurt your eyes. Do not stare into the lamp when the system is in operation. If you want to replace the photometer lamp, first switch off the Main Power and then wait at least 15 minutes for the lamp to cool down before touching it. Do not touch the lamp before it cools down, or you may get burned.

4

Foreword

Preventing Laser Radiation Please observe the following instructions to prevent personal injury caused by laser radiation.

CAUTION Light sent by the bar code reader may hurt your eyes. Do not stare into the laser beam from the bar code reader.

Preventing Infection Please observe the following instructions to protect against the biohazardous infection.

BIOHAZARD Inappropriately handling samples, controls and calibrators may lead to biohazardous infection. Do not touch the sample, mixture or waste with your hands. Wear gloves and lab coat and, if necessary, goggles. In case your skin contacts the sample, control or calibrator, follow standard laboratory safety procedure and consult a doctor.

Handling Reagents and Wash Solution WARNING Reagents, concentrated wash solution and enhanced wash solution are corrosive to human skins. Exercise caution when using the reagents, concentrated wash solution and enhanced wash solution. In case your skin or clothes contact the reagents or wash solution, wash them off with soap and clean water. In case the reagents or wash solution spill into your eyes, rinse them with much water and consult an oculist.

Treating Waste Liquids Please observe the following instructions to prevent environmental pollution and personal injury caused by waste.

BIOHAZARD Some substances in reagent, control, enhanced wash solution and waste are subject to regulations of contamination and disposal. Dispose of them in accordance with your local or national guidelines for biohazard waste disposal and consult the manufacturer or distributor of the reagents for details. Wear gloves and lab coat and, if necessary, goggles.

Treating Waste Analyzer Please observe the following instructions to dispose of the waste analyzer.

Foreword

5

WARNING Materials of the analyzer are subject to contamination regulations. Dispose of the waste analyzer in accordance with your local or national guidelines for waste disposal.

Preventing Fire or Explosion Please observe the following instructions to prevent fire and explosion.

WARNING Ethanol is flammable substance. Please exercise caution while using the ethanol.

6

Foreword

Precautions on Use To use the BS-400/BS-420 Chemistry Analyzer safely and efficiently, please pay much attention to the following operation notes.

Intended Use WARNING The BS-400/BS-420 is a fully-automated and computer-controlled chemistry analyzer designed for in vitro quantitative determination of clinical chemistries in serum, plasma, urine and CSF samples. Please consult Mindray first if you want to use the system for other purposes. To draw a clinical conclusion, please also refer to the patient’s clinical symptoms and other test results.

Operator WARNING The BS-400/BS-420 is to be operated only by clinical professionals, doctors or laboratory experimenters trained by Mindray or Mindray-authorized distributors.

Environment CAUTION Please install and operate the system in an environment specified by this manual. Installing and operating the system in other environment may lead to unreliable results and even equipment damage.

Foreword

7

Preventing Interference by Electromagnetic Noise CAUTION Electromagnetic noise may interfere with operations of the system. Do not install devices generating excessive electromagnetic noise around the system. Do not use such devices as mobile phones or radio transmitters in the room housing the system. Do not use other CRT displays around the system. Do not use other medical instruments around the system that may generate electromagnetic noise to interfere with their operations. Do not use this device in close proximity to sources of strong electromagnetic radiation (e.g. mobile phones or radio transmitters), as these may interfere with the proper operation. The electromagnetic environment should be evaluated prior to operation of the device. This device has been designed and tested to CISPR 11 Class A, and in a domestic environment may cause radio interference, in which case, you may need to take measures to mitigate the interference.

Operating the System CAUTION Operate the system strictly as instructed by this manual. Inappropriate use of the system may lead to unreliable test results or even equipment damage or personal injury. Before using the system for the first time, run the calibration program and QC program to make sure the system is in proper status. Be sure to run the QC program every time you use the system, otherwise the result may be unreliable. Do not open the covers of the sample disk and reagent disk when the system is in operation. The RS-232 port on the analyzing unit is to be used for connection with the operation unit only. Do not use it for other connections. Only use the supplied cable for the connection. The operation unit is a personal computer with the BS-400/BS-420 operating software installed. Installing other software or hardware on this computer may interfere with the system operation. Do not run other software when the system is working. Computer virus may destroy the operating software or test data. Do not use this computer for other purposes or connect it to the Internet. Do not touch the display, mouse or keyboard with wet hands or hands with chemicals. Do not place the Main Power to ON again within 10 seconds since placing it to OFF; otherwise the system may enter protection status. If it does so, switch off the Main Power and switch it on again.

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Foreword

Maintaining the System CAUTION Maintain the system strictly as instructed by this manual. Inappropriate maintenance may lead to unreliable results, or even equipment damage and personal injury. To wipe off dust from the system surface, use a soft, clean and wet (not too wet) cloth, soaked with mild soap solution if necessary, to clean the surface. Do not use such organic solvents as ethanol for cleaning. After cleaning, wipe the surface with dry cloth. Switch off all the powers and unplug the power cord before cleaning. Take necessary measures to prevent water ingression into the system, otherwise it may lead to equipment damage or personal injury. Replacement of such major parts as lamp, photometer, sample probe, reagent probe, mixer and syringe plunger assembly must be followed by a calibration.

Samples CAUTION Use samples that are completely free of insoluble substances like fibrin, or suspended matter; otherwise the probe may be blocked. Medicines, anticoagulants or preservative in the samples may lead to unreliable results. Hemolysis, icterus or lipemia in the samples may lead to unreliable test results, so a sample blank is recommended. Store the samples properly. Improper storage may change the compositions of the samples and lead to unreliable results. Sample volatilization may lead to unreliable results. Do not leave the sample open for a long period. Some samples may not be analyzed on the BS-400/BS-420 based on parameters the reagents claim capable of testing. Consult the reagent manufacturer or distributor for details. Certain samples need to be processed before being analyzed by the system. Consult the reagent manufacturer or distributor for details. The system has specific requirements on the sample volume. Refer to this manual for details. Load the sample to correct position on the sample disk before the analysis begins; otherwise you will not obtain correct results.

Setting up the System CAUTION To define such parameters as sample volume, reagent volume and wavelength, follow the instructions in this manual and the package insert of the reagents.

Foreword

9

Reagents, Calibrators and Controls CAUTION Use appropriate reagents, calibrators and controls on the system. Select appropriate reagents according to performance characteristic of the system. Consult the reagent suppliers, Mindray or Mindray-authorized distributor for details, if you are not sure about your reagent choice. Store and use reagents, calibrators and controls strictly as instructed by the suppliers. Otherwise, you may not obtain reliable results or best performance of the system. Improper storage of reagents, calibrators and controls may lead to unreliable results and bad performance of the system even in validity period. Perform a calibration after changing reagents. Otherwise, you may not obtain reliable results. Contamination caused by carryover among reagents may lead to unreliable test results. Consult the reagent manufacturer or distributor for details.

Backing up Data NOTE The system can automatically store data to the built-in hard disk of the PC. However, data loss is still possible due to mis-deletion or physical damage of the hard disk. Mindray recommends you to regularly back up the data to portable storage device.

Computer and Printer NOTE Refer to the operation manuals of computer and printer for details.

External Equipment WARNING External equipment connected to the system, such as PC and printer, shall be consistent with IEC 60950, EN 60950, EN55022 (Class B) and EN55024.

10

Foreword

Contents Foreword ........................................................................................................... 1 Who Should Read This Manual.......................................................................................... 1 What Can You Find in This Manual .................................................................................... 1 Conventions Used in This Manual...................................................................................... 1 Safety Precautions ............................................................................................................. 4 Precautions on Use ............................................................................................................ 7

Contents............................................................................................................. I 1

System Description .............................................................................. 1-1 1.1 1.2 1.3

2

System Performance and Workflow ................................................... 2-1 2.1

2.2

3

Overview............................................................................................................... 1-1 System Components ............................................................................................ 1-2 Functions .............................................................................................................. 1-3

Technical Specifications........................................................................................ 2-1 2.1.1 General .................................................................................................... 2-1 2.1.2 Specifications for Sample System ........................................................... 2-2 2.1.3 Specifications for Reagent System.......................................................... 2-3 2.1.4 Specifications of Reaction System .......................................................... 2-5 2.1.5 Specifications of Operation...................................................................... 2-6 2.1.6 Installation Requirements ........................................................................ 2-6 2.1.7 Optional Modules..................................................................................... 2-7 Timing Principle .................................................................................................... 2-7 2.2.1 Overview.................................................................................................. 2-7 2.2.2 Timing ...................................................................................................... 2-7 2.2.3 Test Workflow......................................................................................... 2-10 2.2.4 Measuring Points ................................................................................... 2-11

Installation Procedures ........................................................................ 3-1 3.1 3.2

3.3

Environmental Requirements ............................................................................... 3-1 Installation Requirements ..................................................................................... 3-2 3.2.1 Space and Accessibility Requirements.................................................... 3-2 3.2.2 Power Requirements ............................................................................... 3-2 3.2.3 Water Supply and Drainage Requirements ............................................. 3-2 3.2.4 Connecting Water Supply and Drain Facilities ........................................ 3-4 3.2.5 Connecting Water Unit(Optional)............................................................. 3-5 Installation Procedures ......................................................................................... 3-8 3.3.1 Checking before Intallation ...................................................................... 3-8 3.3.2 Unpacking ................................................................................................ 3-8 3.3.3 Install Drawer and Air Pump .................................................................. 3-12 3.3.4 Install the Probe and the Mixing Bar...................................................... 3-14 3.3.5 Connect the System .............................................................................. 3-19 3.3.6 Run debug software............................................................................... 3-19 3.3.7 Operation Software Installation.............................................................. 3-24 3.3.8 Run Operating Software ........................................................................ 3-26 3.3.9 System Set up & Test ............................................................................ 3-27

Contents

I

3.3.10

4

Units and Modules................................................................................ 4-1 4.1

4.2

4.3

4.4

4.5

4.6

4.7

4.8

5

Sample/Reagent Probe Unit................................................................................. 4-1 4.1.1 Introduction .............................................................................................. 4-1 4.1.2 Components and Structure ...................................................................... 4-1 4.1.3 Installation................................................................................................ 4-4 Sample Disk Unit .................................................................................................. 4-4 4.2.1 Introduction .............................................................................................. 4-4 4.2.2 Components and Structure ...................................................................... 4-4 4.2.3 Servicing .................................................................................................. 4-5 Reagent Disk Unit............................................................................................... 4-11 4.3.1 Introduction ............................................................................................ 4-11 4.3.2 Components and Structure .................................................................... 4-12 4.3.3 Servicing the Reagent Disk Unit............................................................ 4-15 Reaction Disk Unit .............................................................................................. 4-21 4.4.1 Introduction ............................................................................................ 4-21 4.4.2 Components and Structure .................................................................... 4-22 4.4.3 Replacing Components and Parts ......................................................... 4-23 4.4.4 Installing Reaction Disk Drive Part ........................................................ 4-23 4.4.5 Installing Reaction Disk Motor Assembly............................................... 4-25 4.4.6 Installing Coder Sensor Assembly......................................................... 4-26 4.4.7 Installing Reaction Compartment Assembly .......................................... 4-27 4.4.8 Installing Reaction Disk Assembly......................................................... 4-28 Mixer Unit............................................................................................................ 4-29 4.5.1 Introduction ............................................................................................ 4-29 4.5.2 Components and Structure .................................................................... 4-29 4.5.3 Installation.............................................................................................. 4-31 Photometric Unit ................................................................................................. 4-32 4.6.1 Introduction ............................................................................................ 4-32 4.6.2 Components and Structure .................................................................... 4-33 4.6.3 Adjustment of Photometer ..................................................................... 4-35 4.6.4 Replacing Tungsten-halogen Lamp....................................................... 4-41 4.6.5 Replacing Optical Assembly .................................................................. 4-42 Wash Unit ........................................................................................................... 4-43 4.7.1 Introduction ............................................................................................ 4-43 4.7.2 Functions ............................................................................................... 4-43 4.7.3 Structure and Installation ....................................................................... 4-44 ISE Unit(optional)................................................................................................ 4-46 4.8.1 Introduction ............................................................................................ 4-46 4.8.2 Components and Structure .................................................................... 4-46

Hydropneumatic System ..................................................................... 5-1 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 5.10

II

Training ................................................................................................ 3-28

Introduction ........................................................................................................... 5-1 Function Block Diagram ....................................................................................... 5-3 Schematic Diagram of Fluidic System.................................................................. 5-4 Connectors ........................................................................................................... 5-5 Tubing ................................................................................................................. 5-12 Solenoid Valves .................................................................................................. 5-32 Layout of Hydropneumatic Drawer ..................................................................... 5-34 Structure of Air Pump Assembly ......................................................................... 5-37 Water Supply Module(optional) .......................................................................... 5-39 Key Components............................................................................................. 5-42

Contents

6

Hardware ............................................................................................... 6-1 6.1 6.2 6.3 6.4 6.5 6.6

6.7

6.8

7

Replacement of Other Components and Parts .................................. 7-1 7.1 7.2 7.3 7.4 7.5 7.6

8

Overview............................................................................................................... 6-1 Safety Precautions................................................................................................ 6-1 Circuit boards........................................................................................................ 6-1 Layout of the boards ............................................................................................. 6-4 Detaching and Assembling Circuit Boards ........................................................... 6-4 Function of board.................................................................................................. 6-4 6.6.1 Control Framework .................................................................................. 6-4 6.6.2 Main Board .............................................................................................. 6-5 6.6.3 Three-disk Drive Board............................................................................ 6-6 6.6.4 Three-probe Drive Board ......................................................................... 6-7 6.6.5 Pre-amp Board ........................................................................................ 6-8 6.6.6 AD Conversion Board .............................................................................. 6-8 6.6.7 Reagent Refrigeration Board................................................................... 6-9 6.6.8 Level Detection Board ............................................................................. 6-9 6.6.9 Clot Detection Board.............................................................................. 6-10 6.6.10 Pump/Valve Drive Board...................................................................... 6-10 6.6.11 Reaction Disk Temperature Control Board .......................................... 6-11 6.6.12 Preheat Temperature Control Board.................................................... 6-11 6.6.13 Communication Board ......................................................................... 6-11 Power Supply Module......................................................................................... 6-11 6.7.1 Features of Power Supply Module ........................................................ 6-12 6.7.2 Block Diagram ....................................................................................... 6-13 Connection Diagram ........................................................................................... 6-15

Overview............................................................................................................... 7-1 Enclosure and Panel............................................................................................. 7-1 Replacing Valves and Tanks................................................................................. 7-6 Installing Sample Syringe ................................................................................... 7-10 Installing Reagent Syringe.................................................................................. 7-11 Installing Power Supply Assembly...................................................................... 7-12

Service and Maintenance..................................................................... 8-1 8.1

8.2

8.3

Preparation ........................................................................................................... 8-1 8.1.1 Tools......................................................................................................... 8-2 8.1.2 Wash Solution.......................................................................................... 8-2 8.1.3 Others ...................................................................................................... 8-2 Daily Maintenance ................................................................................................ 8-2 8.2.1 Checking Sample/Reagent Syringes....................................................... 8-2 8.2.2 Checking/Cleaning Sample Probe........................................................... 8-3 8.2.3 Checking/Cleaning R1/R2 Probes........................................................... 8-3 8.2.4 Checking/Cleaning Sample/Reagent Mixers ........................................... 8-3 8.2.5 Checking Connection of Deionized Water............................................... 8-3 8.2.6 Checking Waste Tubing........................................................................... 8-4 8.2.7 Checking Vacuum/Pressure Pumps ........................................................ 8-4 8.2.8 Checking Printer/Printing Paper .............................................................. 8-5 8.2.9 ISE Unit (optional).................................................................................... 8-5 Weekly Maintenance ............................................................................................ 8-6 8.3.1 Cleaning Sample Probe........................................................................... 8-6 8.3.2 Cleaning R1/R2 Probes ........................................................................... 8-8 8.3.3 Cleaning Sample/Reagent Mixers ......................................................... 8-10 8.3.4 Cleaning Sample/Reagent Bar Code Reader Windows........................ 8-11

Contents

III

8.4 8.5

8.6 8.7

8.8

8.9

9

Test and Maintenance Software .......................................................... 9-1 9.1

9.2

IV

8.3.5 Cleaning Sample Disk/Compartment .................................................... 8-11 8.3.6 Cleaning Reagent Disk/Compartment ................................................... 8-12 8.3.7 Cleaning Panels of Analyzing Unit......................................................... 8-13 8.3.8 Cleaning Reaction Cuvettes .................................................................. 8-14 8.3.9 Checking Photometer ............................................................................ 8-14 8.3.10 Checking Concentrated Wash Solution ............................................... 8-19 Two-week Maintenance ...................................................................................... 8-19 8.4.1 Maintaining Hydropneumatic Components............................................ 8-19 Monthly Maintenance.......................................................................................... 8-20 8.5.1 Cleaning Wash Well of Sample Probe................................................... 8-20 8.5.2 Cleaning Wash Well of R1/R2 Probes................................................... 8-21 8.5.3 Cleaning Wash Well of Sample/Reagent Mixers................................... 8-22 8.5.4 Cleaning Sample Probe Rotor............................................................... 8-23 8.5.5 Cleaning R1/R2 Probes Rotors ............................................................. 8-24 8.5.6 Cleaning Sample/Reagent Mixers Rotors ............................................. 8-25 8.5.7 Checking Wash Unit .............................................................................. 8-26 8.5.8 Checking Hydropneumatic Drawer........................................................ 8-29 8.5.9 Cleaning Air Filter, Oil Mist Separator, Mist Separator .......................... 8-30 8.5.10 Replacing Reaction Cuvette ................................................................ 8-30 Three-month Maintenance ................................................................................. 8-33 8.6.1 Cleaning Dust Screens .......................................................................... 8-33 Six-month Maintenance ...................................................................................... 8-33 8.7.1 Replacing Lamp..................................................................................... 8-33 8.7.2 Replacing or Cleaning Air Screen.......................................................... 8-36 8.7.3 Cleaning Tanks, Floater Switch and Siphon Tube ................................. 8-36 8.7.4 Maintaining the Air Pump....................................................................... 8-36 8.7.5 Replacing Waste Tubing........................................................................ 8-37 8.7.6 Replacing First and Second Phase Washing Tubing on Wash Unit...... 8-37 8.7.7 Replacing DI Water Filter and the Tubing.............................................. 8-39 8.7.8 Replacing On-line Filters and Check Valves ......................................... 8-39 As-Needed Maintenance .................................................................................... 8-45 8.8.1 Unclogging Sample Probe ..................................................................... 8-45 8.8.2 Unclogging R1/R2 Probes ..................................................................... 8-50 8.8.3 Replacing Sample Probe ....................................................................... 8-54 8.8.4 Cleaning Wash Well of Sample Probe................................................... 8-55 8.8.5 Replacing R1/R2 Probes ....................................................................... 8-56 8.8.6 Replacing Sample/Reagent Mixers ....................................................... 8-56 8.8.7 Replacing Syringe Plunger Assembly.................................................... 8-58 8.8.8 Removing Air Bubbles ........................................................................... 8-60 8.8.9 Replacing Reaction Cuvette .................................................................. 8-61 Maintaining ISE Module(Optional)...................................................................... 8-64 8.9.1 Replacing Reagent Pack ....................................................................... 8-64 8.9.2 Replacing Electrodes............................................................................. 8-64 8.9.3 Replacing Tubing ................................................................................... 8-65 8.9.4 ISE Unit Storage (optional) .................................................................... 8-65

Basic Operations .................................................................................................. 9-1 9.1.1 Logging On .............................................................................................. 9-1 9.1.2 Overview.................................................................................................. 9-1 9.1.3 Operating Commands.............................................................................. 9-3 Macro Instructions .............................................................................................. 9-10 9.2.1 Function ................................................................................................. 9-10

Contents

9.3

9.4

10

Troubleshooting ................................................................................. 10-1 10.1 10.2

11

9.2.2 Detailed Operations ............................................................................... 9-10 Performance ....................................................................................................... 9-13 9.3.1 Accuracy and Repeatability of Absorbance ........................................... 9-13 9.3.2 Stability of Absorbance .......................................................................... 9-14 9.3.3 Linearity of Absorbance ......................................................................... 9-15 9.3.4 Absorbance Accuracy and Precision of Diluted Sample ....................... 9-15 9.3.5 Residue of Cuvette ................................................................................ 9-16 9.3.6 Sampling Accuracy and Precision of Sample Probe ............................. 9-16 9.3.7 Carryover of Sample Probe ................................................................... 9-16 9.3.8 Backwater .............................................................................................. 9-17 9.3.9 Stability and Drift of Absorbance............................................................ 9-17 Parameter ........................................................................................................... 9-19 9.4.1 Detailed Operations ............................................................................... 9-19

Classification of Error Messages .................................................................... 10-2 Corrective Measures....................................................................................... 10-4 10.2.1 Failures of Operation Unit.................................................................... 10-4 10.2.2 Failures of Analyzing Unit .................................................................. 10-13

Calculation Methods .......................................................................... 11-1 11.1

11.2

11.3

Reaction Types ............................................................................................... 11-1 11.1.1 Endpoint ............................................................................................... 11-1 11.1.2 Fixed-time ............................................................................................ 11-5 11.1.3 Kinetic .................................................................................................. 11-8 Prozone Check.............................................................................................. 11-14 11.2.1 Antigen Addition ................................................................................. 11-14 11.2.2 Reaction Rate Method ....................................................................... 11-16 Serum Index.................................................................................................. 11-17 11.3.1 What is Serum Index.......................................................................... 11-17 11.3.2 Calculation of Serum Index................................................................ 11-18

Contents

V

1

System Description

There is no difference between BS-400 chemistry analyzer and BS-420 chemistry analyzer in system composition and fuctions except for the model.

1.1 Overview The BS-400/BS-420 is a fully-automated and computer-controlled chemistry analyzer designed for in vitro quantitative determination of clinical chemistries in serum, plasma, urine and CSF (Cerebrospinal fluid) samples. The BS-400/BS-420 Chemistry Analyzer consists of the analyzing unit (analyzer) and operation unit. Figure 1-1 Analyzing Unit and Operation Unit

1 System Description

1-1

1.2 System Components The BS-400/BS-420 has a throughput of 400 tests/hour for single- or double-reagent analysis. Each working period is equivalent to 9 seconds. Structurally, the BS-400/BS-420 realizes the “three-disk + three-probe + two-mixer” scheme, which means one reaction disk, one sample disk, one reagent disk, two reagent probes, one sample probe, one sample mixer and one reagent mixer. The two reagent probes aspirate and dispense R1 and R2, and the two mixers stir S(sample) and R2.The photometric system, which is composed of gratings and diode array, perform photometric measurement to the reaction cuvettes that hold sample/reagent mixture. When analysis is finished, the wash unit cleans the reaction cuvettes during 8 phases.

1-2

1 System Description

Figure 1-2 Layout of the system panel

Figure 1-3 System structure

Wash unit Reagent mixer

Sample mixer

Sample probe R1 probe

Reaction disk Sample disk

R2 probe Reagent disk

Hydropneumatic assembly

1.3 Functions The general working procedure of the BS-400/BS-420 is as follows: 1. All mechanical units are initialized.

1 System Description

1-3

2. The reaction cuvettes are washed during 8 phases. After phase 6, water blank is analyzed automatically. 3. The reagent disk rotates to R1 aspirate position, and R1 probe aspirates reagent from a bottle on the reagent disk. 4. When washed for 8 phases, the reaction cuvettes are carried to the reagent dispense position, and the R1 probe rotates to the reaction disk and dispenses the reagent to a cuvette. 5. R1 is incubated in reaction cuvette for several periods. 6. The sample disk rotates to the sample aspirate position, and the sample probe aspirates designated amount of sample from specified sample tube. 7. The reaction cuvette with R1 dispensed rotates to the sample dispense position, and the sample probe dispenses the sample in the reaction cuvette. 8. With sample dispensed, the reaction cuvette rotates to sample mixing position for stirring. 9. In case of double-reagent tests, when sample is dispensed, the reagent disk rotates to the R2 aspirate position, and the R2 probe aspirates reagent from the specified bottle on the reagent disk. 10. The reaction disk with sample dispensed rotates to the R2 dispensing position, and the R2 probe dispenses the reagent to a reaction cuvette. 11. With R2 dispensed, the reaction cuvette is carried to the reagent mixing position for stirring. 12. During each period, the reaction cuvette receives photometric measurement (absorbance reading taking) when passing by the photometric unit. 13. Triple-/quadruple-reagent analysis is similar to single-/double-reagent analysis stated above. As for triple- or quadruple-reagent tests, the reaction cuvette with R2 dispensed will not be washed when passing by the wash unit. 14. The reaction cuvettes in which reaction is finished are washed when passing by the wash unit. Table 1-1 Functions of system units

1-4

Unit Name Sample probe unit

Description Aspirates and dispenses samples for all chemical and ISE tests.

Sample Disk Unit

90 positions. Holds samples to be analyzed.

R1 probe unit

Aspirates and dispenses R1 and R3 for all chemical tests.

R2 probe unit

Aspirates and dispenses R2 and R4 for all chemical tests.

Reagent Disk Unit

80 positions. Holds bottles containing reagents and wash solution.

Reaction Disk Unit

90 cuvette positions. It provides an environment in which sample reacts with reagents.

Reagent mixer unit

Stirs the mixture in reaction cuvette when R2 is

1 System Description

dispensed. Sample mixer unit

Stirs the mixture in reaction cuvette when sample is dispensed.

Photometric Unit

Performs photometric measurement (absorbance reading) at 12 wavelengths with the gratings system.

Wash Unit

Cleans reaction cuvettes during 8 phases.

ISE Unit(optional)

Measures the concentration of Na+, K+, Cl- and Li+ in serum, plasma and diluted urine.

1 System Description

1-5

2

System Performance and Workflow

2.1 Technical Specifications 2.1.1 General „

System

Random, multi-channel, multi-test „

System structure

Analyzing unit plus Operation unit(PC) „

Sample type

Serum, urine and plasma „

Number of simultaneous measurements

38 double-reagent tests/77 single-reagent tests „

Throughput

400 tests/hour, or 560 tests/hour with ISE unit „

Analytical method

Endpoint, Kinetic, Fixed-time;

2 System Performance and Workflow

2-1

Supporting single-/double-/triple-/quadruple-reagent tests; Supporting single-/double-wavelength tests „

Reaction time

Maximum of 10 minutes „

Reaction temperature

37±0.1℃ „

Test scope

Clinical chemistries, immunoassays, TDM (Therapeutic Drug Monitoring) „

Predilution

Dilution ratio < 150. Dilution is done in reaction cuvette. „

Operation mode

System and tests are configured via the operating software. Profiles and calculation tests are allowed. „

Data processing

Capable of storing and outputting various data and tables/graphs, and calculating among different tests „

Dimensions

l×b×h:1180 mm×700 mm×1145 mm. „

Weight

250 kg „

Emergent samples

Emergent samples can be inserted during measurement at any time. „

Network connection

Able to be connected with LIS (Laboratory Information Management System)

2.1.2 Specifications for Sample System „

Sample loading

Samples are loaded via the sample disk. „

Sample tube type

Microtube: Φ12×37mm, Φ14×25mm; Blood collecting tube: Φ12×68.5 mm, Φ12×99 mm, Φ12.7×75 mm, Φ12.7×100 mm, Φ13 X 75 mm, Φ13 X 95 mm, Φ13 X 100 mm; Plastic tube: Φ12×68.5 mm, Φ12×99 mm, Φ12.7×75 mm, Φ12.7×100 mm, Φ13 X 75 mm, Φ13 X 95 mm, Φ13 X 100 mm.

2-2

2 System Performance and Workflow

„

Sample inventory

The level of samples should be higher than 5mm. „

Sample disk

Ordinary sample disk, including inner, middle and outer circles „

Sample positions on sample disk

90 positions, which include the positions for calibrators, contros, STAT samples and diluted samples „

STAT sample

Emergent samples can be inserted during measurement at any time and then run with high priority. „

Sample volume

2µl-45µl, with increment of 0.1µl „

Sample probe

One probe, which is capable of detecting liquid level, clots and obstruction (in horizontal and vertical directions), and of tracking liquid level „

Sample probe washing

Inside and outside of the probe are washed with carryover less than 0.1%. „

Sample entering mode

Bar code system, etc Table 2-1 Specifications of sample bar code Name Symbology

Description Codabar, ITF(interleaved 2 of 5), code128, code39, UPC/EAN and Code93

Maximum bar code density Total length

0.19mm

Bar code format and contents Max. width of bar code level Min. height of bar code label Max. inclination angle Print quality

User-defined

Wide and narrow ratio

2.5:1 to 3.0:1

3-27 digits

55mm 10mm ±5 degree No less than class C (ANSI MH10.8M)

2.1.3 Specifications for Reagent System „

Reagent loading

All reagents are loaded via the reagent disk.

2 System Performance and Workflow

2-3

„

Reagent bar code

The reagent bar code is in conformity with the NCCLS standard and also compatible with various application environments. The total length of reagent bar code is within 15-30 digits. Table 2-2 Specifications of reagent bar code Name Symbology Maximum bar code density Total length Bar code format and contents Max. width of bar code level Min. height of bar code label Max. inclination angle Print quality Wide and narrow ratio „

Description Codabar, I 2 of 5 (interleaved 2 of 5), code128, code39, UPC/EAN and Code93 0.19mm 15-30 digits User-defined 55mm 10mm ±5 degree Class A (ANSI MH10.8M) 2.5:1 to 3.0:1

Reagent refrigeration

Refrigeration temperature: 4-10℃ „

Reagent dispensing

Reagent is aspirated and dispensed precisely by syringes. „

Reagent types

1 to 4 reagent types, R1, R2, R3 and R4 „

Reagent volume

20µl-350µl, with increment of 1µl „

Reagent disk

Ordinary reagent disk, including inner and outer circles, 80 positions in total „

Reagent bottle

80 reagent bottles can be held on the reagent disk. Each reagent position can hold common 100ml or 70ml bottles or Mindray outer-circle 20ml/40ml and Mindray inner-circle 40ml/62ml bottles. „

Reagent probe

Two separate probes, which are capable of detecting liquid level and obstructions (in horizontal and vertical directions), and tracking liquid level „

Reagent probe washing

Inside and outside of the probe are washed with carryover less than 0.1%.

2-4

2 System Performance and Workflow

„

Reagent inventory

Less than 300µl „

Methods to prevent reagent carryover

User-defined. Reagent probes are washed with enhanced wash solution.

2.1.4 Specifications of Reaction System „

Optical path of reaction cuvette

5mm „

Material of reaction cuvette

5mm×5mm×30mm, semi-permanent plastic reaction cuvette „

Number of reaction cuvettes

90 „

Stirring method

Two separate mixers, which stir samples and R2/R3/R4 respectively „

Reaction liquid volume

150-360µl „

Photometric system

Static fiber transmission, and reversed optics of holographic concave flat-field gratings „

Wavelength

12 wavelengths, which are 340nm, 380nm, 412nm, 450nm, 505nm, 546nm, 570nm, 605nm, 660nm, 700nm, 740nm and 800nm „

Light source

12V, tungsten-halogen lamp, 50W The light is transmitted through the fibers. „

Gratings type

Reversed optics of holographic concave flat-field gratings „

Wavelength accuracy

±2nm „

Minimum reaction liquid volume

150µl „

Photometric measurement method

Photodiode array „

Number of simultaneous wavelength for each test

2 System Performance and Workflow

2-5

One or two wavelengths „

Measurement range

0-3A; optical path: 10mm „

Resolution of photometer

0.001OD

2.1.5 Specifications of Operation „

Calibration method

Linear (one-point, two-point and multi-point), Logit-Log 4p, Logit-Log 5p, Spline, Exponential, Polynomial and Parabola „

Display

15” LCD „

Operating system

Windows 2000 Professional or Windows XP „

QC(quality control) rule

Westgard multi-rule, Cumulative sum check and Twin Plot „

Communication interface

RS-232 „

Printer

Ink jet printer, laser printer (black-white) and stylus printer „

Input device

Keyboard, network „

Output device

Display, printer and LIS host „

Storage device

Hard disk, USB port

2.1.6 Installation Requirements „

Power requirements

AC 220-240V, 50Hz, 1500VA; AC 220/230V, 60Hz, 1500VA; AC 110/115V, 60Hz, 1500VA „

Water consumption

Daily Maint. page. Restart analyzing unit and operation unit. Contact equipment developer Check if U disk or floppy disk is inserted or full. Check if storage device is damaged

Check if U disk or floppy disk is inserted or full. Check if storage device is damaged

Insufficient acid wash solution on reagent disk

Add acid wash solution on specified position of reagent disk

Insufficient alkaline wash solution on reagent disk

Add alkaline wash solution on specified position of reagent disk

Insufficient distilled water on reagent disk

Add distilled water on specified position of reagent disk

10 Troubleshooting

10-11

Error Code

Level

Error Message

C0711

0

C0712

0

C0713

3

Insufficient acid wash solution on sample disk Insufficient alkaline wash solution on sample disk Insufficient distilled water on sample disk

C0714

Probable Causes

Corrective Actions

Insufficient acid wash solution on sample disk

Add acid wash solution on specified position of sample disk

Insufficient alkaline wash solution on sample disk

Add alkaline wash solution on specified position of sample disk

Insufficient distilled water on sample disk

Add distilled water on specified position of sample disk

Lamp aged. Lamp is not turned on. Lamp is loose. All cuvettes are dirty

Check if lamp is turned on, and check the cuvettes on Utilities-->Daily Maint. Page, then replace the cuvettes marked by colors. Check the lamp on If failure remains, replace the lamp Utilities-->Daily Maint. Page. If light intensity is not strong enough, replace the lamp. If failure still remains, contact equipment developer

Blank of cuvette %s exceeds limit

Cuvette is dirty. The amount of water to measure the six-th phase water blank is not enough. Light intensity is too weak

Check if lamp is turned on, and check the cuvettes on Utilities-->Daily Maint. Page, then replace the cuvettes marked by colors. Check the lamp on If failure remains, replace the lamp Utilities-->Daily Maint. Page. If light intensity is not strong enough, replace the lamp. If failure still remains, contact equipment developer

Received data overflow

Received data is too much and exceeds buffer capacity

Contact developer

equipment

Sent data overflow

Instruction buffer is full

Contact developer

equipment

12

Light intensity is weak

C0715

10-12

0

C0716

11

C0717

11

10 Troubleshooting

sending

Error Code

Level

C0718

14

Error Message

Probable Causes

Corrective Actions

ISE test results are not received in given time; ISE module is not connected correctly

Calibrate the ISE module when the system is paused or idle. If problem occurs continuously for 3 times or other error occurs, contact the developer

Lamp is not turned on

Lamp is not turned on; bulb is damaged; no lamp is installed; lamp is loose; foreign matter exist in three continuous cuvettes to obstruct light path

Check if lamp is installed correctly and turned on. If failure remains after replacing the lamp, contact the develop. Check if foreign matters exist in continuous three cuvettes. Replace the cuvettes if necessary

No reaction cuvettes, or lamp intensity is too strong

No cuvettes are installed in four continuous positions; photoelectric gain exceeds the measurement range

Check if all positions of reaction disk are occupied. If yes, ask our service personnel to adjust the photoelectric gain

Foreign matters exist to obstruct light path so that the measured value is less than 1000

Check for failed cuvette and replace it. If the error remains, check if the lamp is installed tightly. If the error still remains for all new cuvettes, contact our service personnel

ISE test timed out

C0719

C0720

C0721

is

12

12

1 Clots found No.%s cuvette

are in

10.2.2 Failures of Analyzing Unit 10.2.2.1 Main Unit Error Code

Level

A0001

11

A0002

12

Error Message

Probable Causes

Invalid command

Instruction error. information included

Parameter download error

Parameter downloading failed. Parameter configuration error

10 Troubleshooting

format Invalid is

Corrective Actions Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Reset mechanically and retry. If this failure occurs for 3 times, contact the developer

10-13

Error Code

Level

A0003

11

A0004

A0005

A0006

A0007

A0008

10-14

Error Message

Probable Causes

Main unit is busy downloading parameters

Downloading parameters to subunits. Cannot respond to other instruction

Self-test error

Self-test error

Invalid instruction in current status

Instruction error

System is busy. Cannot respond to other operation

Executing other instruction. Cannot respond to current one

Instruction execute error

Instruction error

Memory error

E2PROM error

Photoelectric data is lost

Received data in single period is less than 90

Photoelectric output is abnormal

AD value is too low (below 10) or too high (over 65500)

12

11 execute

11

11 execute

11

A0009

0

A0010

11

read/write

10 Troubleshooting

Corrective Actions Wait for 30-60s and retry. If system does not respond for long time, restore failure. If this problem occurs frequently, contact the developer Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Rerun. If problem occurs frequently, contact the developer If optic measurement assembly goes wrong, replace AD assembly. If AD collection board works normally, remove optic measurement assembly, and check if preamplification board and optical path are normal

Error Code

Level

A0011

11

A0012

11

A0013

A0014

A0015

A0016

Error Message Photoelectric data overflow Photoelectric collection is timed out

Probable Causes

Corrective Actions

Photoelectric data buffer is full. Cannot process new data Photoelectric circuit does not return result via FIFO in specified time

Restart analyzing unit and operation unit Restart analyzing unit and operation unit

11 Downloading failed

Incompatible wrong version

Handshake failed

Connection error. Analyzing unit is performing other operation

11

or

11 Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

11 execute

Restart analyzing unit and replace with new version. If failed again, contact the developer Restart analyzing unit and shake hand. If failed for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.2 Sample Probe Unit Error Code

Level

A0101

6

Error Message

Instruction format error

Probable Causes

Corrective Actions

Instruction error. information included

Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer

10 Troubleshooting

format Invalid is

10-15

Error Code

Level

A0102

11

A0103

A0104

A0105

A0106

A0107

10-16

Error Message

Probable Causes

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy. Unit does not reset mechanically

6

6

11

6

6

Wrong sensor status when sample probe moves vertically(oth er position) Wrong sensor status when sample probe moves vertically(in reaction disk) Sample probe cannot find home position when moving vertically(oth er position) Sample probe cannot find home position when moving vertically(in reaction disk)

Vertical position sensor failure

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Vertical position sensor failure

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

10 Troubleshooting

Error Code

Level

Error Message

A0108

18

Sample probe bumps when moving vertically(oth er position) Sample probe bumps when moving vertically(IS E unit) Sample probe bumps when moving vertically(in reaction disk) Lowering down at current position is not allowed(oth er position) Lowering down at current position is not allowed(in reaction disk) Wrong sensor status when sample probe moves horizontally( other position) Wrong sensor status when sample probe moves horizontally( ISE unit)

A0109

A0110

A0111

A0112

A0113

A0114

18

18

6

11

6

14

Probable Causes

Corrective Actions

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

Sample probe is not in vertical home position. Current position is not proper for lowering down

If auto reset fails, restore failure. If failed for 3 times, contact the developer

Sample probe is not in vertical home position. Current position is not proper for lowering down

If auto reset fails, restore failure. If failed for 3 times, contact the developer

Rotational position sensor failure

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Rotational position sensor failure

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10 Troubleshooting

10-17

Error Code

Level

Error Message

A0115

11

Wrong sensor status when sample probe moves horizontally(i n reaction disk) Sample probe cannot find home position when moving horizontally( other position) Sample probe cannot find home position when moving horizontally(i n reaction disk) Sample probe collides when moving horizontally( other position) Sample probe collides when moving horizontally(i n reaction disk)

A0116

A0117

A0118

A0119

A0120

A0121

10-18

6

11

18

11

6

11

Rotating at current height is not allowed(oth er position) Rotating at current height is not allowed(in reaction disk)

Probable Causes

Corrective Actions

Rotational position sensor failure

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

Sample probe is obstructed or falls when moving horizontally.

If auto reset fails, restore failure. Check motor and belt

Sample probe is obstructed or falls when moving horizontally.

If auto reset fails, restore failure. Check motor and belt

Sample probe is not in horizontal home position. Current height is not proper for rotation(highest position) Sample probe is not in horizontal home position. Current height is not proper for rotation(highest position)

10 Troubleshooting

If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer

Error Code

Level

A0122

6

A0123

3

A0125

11

A0127

A0128

1

3

1

A0129

1

A0130

1

A0131

1

A0132

Probable Causes

Corrective Actions

Syringe sensor is in wrong status

Syringe sensor error

Syringe cannot find home position

Sample syringe reaches maximum stroke. Cannot restore or dispense sample

6

A0124

A0126

Error Message

0

Clog detection error Sample probe does not detect wash solution level Sample probe does not detect liquid level on reaction disk Sample probe does not detect liquid level on sample disk Insufficient sample dispensing volume Sample syringe aspirates too much Sample syringe dispenses too much Sample probe does not aspirate sample Clogs sample

in

Sample clogged

probe

is

If auto reset fails, restore failure. If failed for 3 times, contact the developer Check if sample syringe reaches maximum limit and cannot restore. Restore failure, or reset after pushing syringe to home position. If failed for 3 times, contact the developer Wash sample probe. Remove probe and clear up foreign matters

No deionized water

Add deionized water

No R1 dispensed. Insufficient R1

Check if reagent sufficient. Rerun

is

No sample tube. Sample is already depleted

Check if sample sufficient. Rerun

is

Insufficient sample aspiration volume

Check sample volume and rerun

Sample aspirates abnormally

syringe full

Restore failure. If failed for 3 times, contact the developer

Sample dispenses abnormally

syringe empty

Restore failure. If failed for 3 times, contact the developer

Insufficient sample. Wrong tube type

Add samples or replace with standard sample tube

Clots in sample

Re-centrifugate sample, or remove clots manually

10 Troubleshooting

10-19

Error Code

Level

A0133

11

A0134

Error Message

Probable Causes

Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

11 execute

Corrective Actions Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.3 Sample Disk Unit Error Code

Level

A0201

6

A0202

A0203

A0204

A0205

10-20

Error Message

Probable Causes

Instruction format error

Instruction error. information included

format Invalid is

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

Home position is not found

Cannot find position

Step missed

Belt failure

11

6

6

6

10 Troubleshooting

home

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Error Code

Level

A0206

6

A0207

A0208

A0209

A0210

A0211

15

Error Message

Probable Causes

Corrective Actions

Wrong sensor status

Sensor failure

Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Bar code reader does not work normally

Sample barcode reader is not installed. Barcode reader is not connected to PCB properly

Reboot the analyzer. If problem remains, contact the developer

Bar error

Barcode digit error. Data format error. No end mark

0

15

code

Bar code sending buffer is full

Scanning too many or too fast

Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

11

11 execute

Check if barcode label is dirty, skewed, or placed correctly. Rescan or scan after reprinting Rescan after restoring failure. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.4 R1 Probe Unit Error Code

Level

A0301

4

Error Message

Instruction format error

Probable Causes

Corrective Actions

Instruction error. information included

Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer

10 Troubleshooting

format Invalid is

10-21

Error Code

Level

A0302

11

A0303

A0304

A0305

A0306

A0307

A0308

A0309

10-22

Error Message

Probable Causes

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

Wrong sensor status when R1 probe moves vertically(othe r position)

Vertical position sensor failure

Wrong sensor status when R1 probe moves vertically(in reaction disk)

Vertical position sensor failure

4

4

11

4

11

18

18

R1 probe cannot find home position when moving vertically(othe r position) R1 probe cannot find home position when moving vertically(in reaction disk) R1 probe bumps when moving vertically(othe r position) R1 probe bumps when moving vertically(in reaction disk)

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

10 Troubleshooting

Error Code

Level

Error Message

A0310

4

Lowering down at current position is not allowed(other position) Lowering down at current position is not allowed(in reaction disk)

A0311

A0312

A0313

A0314

A0315

A0316

A0317

A0318

11

Probable Causes

Corrective Actions

R1 probe is not in vertical home position. Current position is not proper for lowering down

If auto reset fails, restore failure. If failed for 3 times, contact the developer

R1 probe is not in vertical home position. Current position is not proper for lowering down

If auto reset fails, restore failure. If failed for 3 times, contact the developer

4

11

4

11

18

11

Wrong sensor status when R1 probe moves horizontally(ot her position)

Rotational position sensor failure

Wrong sensor status when R1 probe moves horizontally(in reaction disk)

Rotational position sensor failure

R1 probe cannot find home position when moving horizontally(ot her position) R1 probe cannot find home position when moving horizontally(in reaction disk) R1 probe collides when moving horizontally(ot her position) R1 probe collides when moving horizontally(in reaction disk)

4 Rotating is not allowed(other position)

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. If this message appears for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

R1 probe is obstructed or falls when moving horizontally

If auto reset fails, restore failure. Check motor and belt

R1 probe is obstructed or falls when moving horizontally

If auto reset fails, restore failure. Check motor and belt

R1 probe is not in horizontal home position. Current height is not proper for rotation(highest position)

If auto reset fails, restore failure. If failed for 3 times, contact the developer

10 Troubleshooting

10-23

Error Code

Level

A0319

11

Error Message Rotating is not allowed(in reaction disk)

A0320

A0321

A0322

A0323

A0324

Corrective Actions

R1 probe is not in horizontal home position. Current height is not proper for rotation(highest position)

If auto reset fails, restore failure. If failed for 3 times, contact the developer

Syringe sensor is in wrong status

Syringe sensor error

Syringe cannot find home position

R1 syringe reaches maximum stroke. Cannot restore or dispense reagent

4

11

1

2

A0325

1

A0326

1

A0327

1

A0328

11

A0329

10-24

4

Probable Causes

R1 probe does not detect wash solution level R1 probe does not detect liquid level on reaction disk R1 probe does not detect liquid level on reagent disk Insufficient R1 dispensing volume R1 syringe aspirates too much R1 syringe dispenses too much

If auto reset fails, restore failure. If failed for 3 times, contact the developer Check if R1 syringe reaches maximum limit and cannot restore. Restore failure, or reset after pushing syringe to home position. If this problem occurs for 3 times, contact the developer

No deionized water

Add deionized water

No R1 or sample or insufficient R1 in reaction cuvette when system dispenses R1 or R3

Check if reagent sufficient. Rerun

is

No reagent on first reagent position. Reagent is depleted

Check if reagent sufficient. Rerun

is

Insufficient R1 aspiration volume

Check reagent volume and rerun

R1 syringe aspirates full abnormally R1 syringe dispenses empty abnormally

Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

11

10 Troubleshooting

execute

Restore failure. If failed for 3 times, contact the developer Restore failure. If failed for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.5 R2 Probe Unit Error Code A0401

A0402

A0403

A0404

A0405

A0406

Level

Error Message

Probable Causes

5 Instruction format error

Instruction error. information included

format Invalid is

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

Wrong sensor status when R2 probe moves vertically(ot her position)

Vertical position sensor failure

11

5

5

11

5

Wrong sensor status when R2 probe moves vertically(in reaction disk) R2 probe cannot find home position when moving vertically(ot her position)

Vertical position sensor failure

Vertical position sensor failure. Obstruction exists in vertical direction

10 Troubleshooting

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Restore failure. If failed for 3 times, contact the developer

10-25

Error Code A0407

A0408

A0409

A0410

A0411

A0412

A0413

10-26

Level 11

18

18

5

11

5

11

Error Message R2 probe cannot find home position when moving vertically(in reaction disk) R2 probe bumps when moving vertically(ot her position) R2 probe bumps when moving vertically(in reaction disk) Lowering down at current position is not allowed(oth er position) Lowering down at current position is not allowed(in reaction disk) Wrong sensor status when R2 probe moves horizontally( other position) Wrong sensor status when R2 probe moves horizontally( in reaction disk)

Probable Causes

Corrective Actions

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

Wrong position. Obstruction exists

If auto reset fails, restore failure. Remove obstruction and reset

R2 probe is not in vertical home position. Current position is not proper for lowering down

If auto reset fails, restore failure. If failed for 3 times, contact the developer

R2 probe is not in vertical home position. Current position is not proper for lowering down

If auto reset fails, restore failure. If failed for 3 times, contact the developer

Rotational position sensor failure

Rotational position sensor failure

10 Troubleshooting

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Error Code A0414

A0415

A0416

A0417

A0418

Level 5

11

18

11

Error Message R2 probe cannot find home position when moving horizontally( other position) R2 probe cannot find home position when moving horizontally( in reaction disk) R2 probe collides when moving horizontally( other position) R2 probe collides when moving horizontally( in reaction disk)

5 Rotating is not allowed(oth er position)

A0419

A0420

A0421

11

5

Rotating is not allowed(in reaction disk)

Probable Causes

Corrective Actions

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

R2 probe is obstructed or falls when moving horizontally

If auto reset fails, restore failure. Check motor and belt

R2 probe is obstructed or falls when moving horizontally

If auto reset fails, restore failure. Check motor and belt

R2 probe is not in horizontal home position. Current height is not proper for rotation(highest position) R2 probe is not in horizontal home position. Current height is not proper for rotation(highest position)

Syringe sensor is in wrong status

Syringe sensor error

Syringe cannot find home position

R2 syringe reaches maximum stroke. Cannot restore or dispense reagent

5

10 Troubleshooting

If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer Check if R2 syringe reaches maximum limit and cannot restore. Restore failure, or reset after pushing syringe to home position. If this problem occurs for 3 times, contact the developer

10-27

Error Code A0422

A0423

A0424

A0425

Level 11

1

2

1

A0426

1

A0427

1

A0428

11

A0429

Error Message R2 probe does not detect wash solution level R2 probe does not detect liquid level on reaction disk R2 probe does not detect liquid level on reagent disk Insufficient R2 dispensing volume R2 syringe aspirates too much R2 syringe dispenses too much

Probable Causes

Corrective Actions

No deionized water

Add deionized water

No R1 or sample or insufficient R1 in cuvette

Check if reagent sufficient. Rerun

is

No reagent on second reagent position. Reagent is depleted

Check if reagent sufficient. Rerun

is

Insufficient R2 aspiration volume

Check reagent volume and rerun

R2 syringe aspirates full abnormally R2 syringe dispenses empty abnormally

Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

11 execute

Restore failure. If failed for 3 times, contact the developer Restore failure. If failed for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.6 Reagent Disk Unit Error Code

Level

A0501

7

Error Message

Instruction format error

10-28

Probable Causes

Corrective Actions

Instruction error. information included

Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer

10 Troubleshooting

format Invalid is

Error Code

Level

A0502

11

A0503

A0504

A0505

A0506

A0507

A0508

A0509

A05010

Error Message

Probable Causes

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

Home position is not found

Cannot find position

Step missed

Belt failure

Wrong sensor status

Sensor failure

Bar code reader does not work normally

Reagent barcode reader is not installed. Barcode reader is not connected to PCB properly

Bar error

Barcode digit error. Data format error. No end mark

7

7

home

7

7

16

0 code

16 Bar code sending buffer is full

Scanning too many or too fast

Execution result is not received in given time

Instruction execution is timed out

11

10 Troubleshooting

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Restore failure. If this message appears for 3 times, contact the developer Restore failure. If this message appears for 3 times, contact the developer Restore failure. If this message appears for 3 times, contact the developer Reboot the analyzer. If problem remains, contact the developer Check if barcode label is dirty, skewed, or placed correctly. Rescan or scan after reprinting Rescan after resetting mechanically. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10-29

Error Code

Level

A05011

11

Error Message

No response, or response error

Probable Causes

Corrective Actions

Instruction error

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

execute

10.2.2.7 Reaction Disk Unit Error Code

Level

A0601

11

A0602

A0603

Instruction format error

Instruction error. information included

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

A0605

11

11

Reaction disk cannot find home position Reaction disk missed step when moving horizontally Reaction disk sensor is in wrong status

12 Light signal too strong

10-30

Corrective Actions

format Invalid is

11

11

A0608

Probable Causes

11

A0604

A0606

Error Message

Reaction disk home position sensor failure. Coder goes wrong Motor failure

failure.

Belt

Sensor failure No cuvette on a specified position or photoelectric gain adjusting error

10 Troubleshooting

Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Restore failure. If this message appears for 3 times, contact the developer Restore failure. If this message appears for 3 times, contact the developer Restore failure. If this message appears for 3 times, contact the developer Load the cuvette or contact the developer and adjust photoelectric gain

A0609

A0610

A0611

A0612

12 Photoelectric buffer is abnormal

Photoelectric overflow, or overflow

buffer FIFO

Photoelectric data error

Photoelectric collection and conversion failed

Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

1

11

11 execute

Switch off analyzing unit power and switch on again. If this message appears for 3 times, contact the developer After testing, switch off analyzing unit power and switch on again. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.8 Reagent Mixer Unit Error Code

Level

A0701

9

A0702

Error Message

Probable Causes

Instruction format error

Instruction format error. Invalid information is included

Instruction parameter error

Instruction parameter does not comply with protocol

9

10 Troubleshooting

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer

10-31

Error Code

Level

A0703

9

A0704

A0705

A0706

A0707

10-32

Error Message

Probable Causes

No execute condition

Unit is busy and does not reset mechanically

Wrong sensor status when reagent mixer moves vertically(other position)

Vertical position sensor failure

Wrong sensor status when reagent mixer moves vertically(in reaction disk)

Vertical position sensor failure

9

11

9

11

A0708

9

A0709

11

Reagent mixer cannot find home position when moving vertically(other position) Reagent mixer cannot find home position when moving vertically(in reaction disk) Lowering down at current position is not allowed(other position) Lowering down at current position is not allowed(in reaction disk)

Corrective Actions Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Reagent mixer is not in vertical home position. Current position is not proper for lowering down Reagent mixer is not in vertical home position. Current position is not proper for lowering down

10 Troubleshooting

If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer

Error Code

Level

A0710

9

A0711

A0712

A0713

A0714

Error Message

Wrong sensor status when reagent mixer moves horizontally(other position)

Rotational position sensor failure

Wrong sensor status when reagent mixer moves horizontally(in reaction disk)

Rotational position sensor failure

11

9

11

Reagent mixer cannot find home position when moving horizontally(other position) Reagent mixer cannot find home position when moving horizontally(in reaction disk)

9 Rotating at current height is not allowed(other position)

A0715

11 Rotating at current height is not allowed(in reaction disk)

A0716

Probable Causes

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

Reagent mixer is not in horizontal home position. Current height is not proper for rotation(highest position) Reagent mixer is not in horizontal home position. Current height is not proper for rotation(highest position)

11 Execution result is not received in given time

Corrective Actions

Instruction execution is timed out

10 Troubleshooting

If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10-33

Error Code

Level

A0717

11

Error Message

No response, or response error

Probable Causes

Corrective Actions

Instruction execute error

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Probable Causes

Corrective Actions

10.2.2.9 Sample Mixer Unit Error Code

Level

A0801

8

A0802

A0803

A0804

10-34

Error Message

Instruction format error

Instruction format error. Invalid information is included

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

Wrong sensor status when sample mixer moves vertically(other position)

Vertical position sensor failure

8

8

8

10 Troubleshooting

Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Error Code

Level

A0805

11

Error Message

Wrong sensor status when sample mixer moves vertically(in reaction disk) A0806

A0807

8

11

A0808

8

A0809

11

A0810

8

A0811

A0812

Sample mixer cannot find home position when moving vertically(other position) Sample mixer cannot find home position when moving vertically(in reaction disk) Lowering down at current position is not allowed(other position) Lowering down at current position is not allowed(in reaction disk)

Probable Causes

Corrective Actions

Vertical position sensor failure

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Vertical position sensor failure. Obstruction exists in vertical direction

Restore failure. If failed for 3 times, contact the developer

Sample mixer is not in vertical home position. Current position is not proper for lowering down Sample mixer is not in vertical home position. Current position is not proper for lowering down

Wrong sensor status when sample mixer moves horizontally(other position)

Rotational position sensor failure

Wrong sensor status when sample mixer moves horizontally(in reaction disk)

Rotational position sensor failure

Sample mixer cannot find home position when moving horizontally(other position)

Rotational position sensor failure. Obstruction exists in horizontal direction

11

8

10 Troubleshooting

If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Restore failure. If failed for 3 times, contact the developer

10-35

Error Code

Level

Error Message

Probable Causes

Corrective Actions

A0813

11

Sample mixer cannot find home position when moving horizontally(in reaction disk)

Rotational position sensor failure. Obstruction exists in horizontal direction

Restore failure. If failed for 3 times, contact the developer

A0814

8 Rotating at current height is not allowed(other position)

A0815

11 Rotating at current height is not allowed(in reaction disk)

A0816

A0817

Sample mixer is not in horizontal home position. Current height is not proper for rotation(highest position) Sample mixer is not in horizontal home position. Current height is not proper for rotation(highest position)

11 Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction execute error

11

If auto reset fails, restore failure. If failed for 3 times, contact the developer If auto reset fails, restore failure. If failed for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

10.2.2.10 Temperature Unit Error Code

Level

A0901

0

Error Message

Instruction format error

10-36

Probable Causes

Corrective Actions

Instruction error. information included

Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer

10 Troubleshooting

format Invalid is

Error Code

Level

A0902

0

A0903

A0904

A0905

A0906

A0907

A0908

Error Message

Probable Causes

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy. Instruction conflicts. Instruction buffer is full

Reaction disk temperature is too high

Reaction disk temperature collection error

Wash solution too hot

Preheat temperature collection error

0

0

0

is

0 Reaction disk temperature is fluctuated

Reaction disk temperature collection error

Wash solution temperature is fluctuated

Preheat temperature collection error

Reaction disk temperature control is switched off

Reaction disk temperature collection error

0

0

10 Troubleshooting

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer

10-37

Error Code

Level

A0909

0

A0910

A0911

0

A0912

0

A0913

11

A0914

A0915

A0916

A0917

10-38

0

Error Message

Probable Causes

Preheat temperature control is switched off

Preheat temperature collection error

Reaction disk temperature is not steady in specified time

Reaction disk temperature collection error. Heater control error

Wash solution temperature is not steady in specified time

Preheat temperature collection error. Heater control error

Refrigerator fans are abnormal

Fan circuit failed. Fan is damaged

Execution result is not received in given time

Instruction execution is timed out

No response, or response error

Instruction error

11

0

0

0

Reaction disk temperature sensor is not connected Preheat temperature sensor is not connected Pressure machine fans abnormal

execute

Corrective Actions Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Reset hardware on Utilities-->Daily Maint. page and restart reaction disk temperature control. If this message appears for 3 times, contact the developer Contact developer

equipment

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Reaction disk temperature sensor is disconnected or damaged

Contact developer

equipment

Preheat temperature sensor is disconnected or damaged

Contact developer

equipment

Fan control circuit error, or fan is damaged

Contact developer

equipment

10 Troubleshooting

10.2.2.11 Wash Unit Error Code

Level

A1001

10

A1002

A1003

A1004

A1005

A1006

A1007

Error Message

Probable Causes

Instruction format error

Instruction error. information included

format Invalid is

Instruction parameter error

Instruction parameter does not comply with protocol

No execute condition

Unit is busy and does not reset mechanically

Instruction execution is timed out

Wash unit is busy or abnormal

Wash unit cannot reach home position

Obstruction exists in vertical direction

Wash unit cannot leave home position

Obstruction exists in vertical direction

Wash unit bumps

Wash unit bumps. Obstruction exists. Mechanical failure

10

10

10

11

10

11

10 Troubleshooting

Corrective Actions Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer Switch off analyzing unit power and switch on again. Download parameters and restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer Reset analyzing unit power and restart operating software. Then retry this instruction. If this message appears for 3 times, contact the developer If auto reset fails, restore failure. Remove obstruction and reset. If problem remains, contact the developer If auto reset fails, restore failure. Remove obstruction and reset. If problem remains, contact the developer Remove foreign matters, and restore failure on Utilities-->Daily Maint. page. If problem remains, contact the developer

10-39

Error Code

Level

Error Message

A1008

17

High-conce ntration waste buffer is too high Low-conce ntration waste buffer is too high

A1009

A1010

A1011

A1012

A1013

A1014

A1015

17

Probable Causes

Corrective Actions

Liquid level sensor is abnormal. Waste buffer is not emptied in time

Empty high-concentration waste buffer

Liquid level sensor is abnormal. Waste buffer is not emptied in time

Empty low-concentration waste buffer

Waste buffer level is too high

Waste pump abnormal. Liquid sensor abnormal. External sewer blocked. Tubing fell off

Troubleshoot failed part

Water tank level is too low

Liquid sensor abnormal. Inlet valve abnormal. Water treatment system abnormal. Water supply unit abnormal. 10psig pressure abnormal

Troubleshoot failed part. Execute "System Prime" and select "Water Tank/Probes/Mixers Prime"

Water tank level is too high

Liquid sensor abnormal. Inlet valve abnormal. Water treatment system abnormal. Water supply unit abnormal. Main filter abnormal

Troubleshoot failed part

Diluted wash tank is too low

Valve abnormal. No diluted wash solution. Water tank level too low. Liquid level sensor abnormal

Troubleshoot failed part. Execute "System Prime" and select "Diluted Wash Solution Tank Prime"

Concentrat ed wash tank is too low

Valve abnormal. No concentrated wash solution. Water tank level too low. Liquid level sensor abnormal

Troubleshoot failed part. Execute "Concentrated Wash Solution Refill"

Pump failure. Valve failure

Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

17

17

17

10

0

11 Pump/valv e goes wrong

10-40

10 Troubleshooting

Error Code

Level

A1016

12

A1017

A1018

A1019

A1020

Error Message

Probable Causes

Corrective Actions

Vacuum pressure is abnormal

Air pump/valve abnormal. Container leakage. Vacuum filter/one-way valve clogged. Connector leakage. Water accumulation in vacuum container

Identify failed part. Check if vacuum level is normal by reading pressure gauge on hydropneumatic assembly panel

25psig pressure is abnormal

Air pump/valve abnormal. High pressure protection of pressure switch started. Protection valve abnormal. Container leakage. Oil separator/one-way valve clogged. Connector leakage

Identify failed part. Check if 25psig is normal by reading pressure gauge on hydropneumatic assembly panel

10psig pressure is abnormal

Air pump/valve abnormal. High pressure protection of pressure switch started. Protection valve abnormal. Container leakage. Oil separator/one-way valve clogged. Connector leakage. Precision regulation valve abnormal

Identify failed part. Check if 10psig is normal by reading pressure gauge on hydropneumatic assembly panel

5psig pressure is abnormal

Air pump/valve abnormal. High pressure protection of pressure switch started. Protection valve abnormal. Container leakage. Oil separator/one-way valve clogged. Connector leakage. Precision regulation valve abnormal

Identify failed part. Check if 5psig is normal by reading pressure gauge on hydropneumatic assembly panel

Wash solution flow for probe interior is abnormal

Interior wash valve abnormal. Water tank level too low. 10psig pressure abnormal. Other valve abnormal

Troubleshoot failed part

12

12

12

12

10 Troubleshooting

10-41

Error Code

Level

Error Message

A1021

12

A1022

A1023

A1024

A1025

A1026

A1027

A1028

A1029

10-42

Probable Causes

Corrective Actions

Wash solution flow for probe/bar exterior is abnormal

Exterior wash valve abnormal

Troubleshoot failed part

Cuvette overflow

Wash probe/tubing/check valve clogged. Vacuum pressure abnormal. Wash unit abnormal

Troubleshoot failed part

No wash solution is dispensed into cuvettes

Wash probe clogged. Connector leakage. 10psig pressure abnormal. Water tank level too low. Preheat module abnormal. Loose connector

Troubleshoot failed part

Air pump cannot start

Tubing pressure not released completely. High pressure protection of pressure switch started

Troubleshoot failed part

Dilution cannot proceed successfull y

Pressure of diluted wash solution tank is not released completely

Troubleshoot failed part

Water accumulate s in reagent disk and wash well

Waste buffer level too high. Waste tubing clogged

Troubleshoot failed part. Arrange waste tubing

Water tank cannot be filled

Water flow is weak, or floater goes wrong

Check the inlet tubing connection. If error remain, contact the developer

Pressure sensor check error

Sensor is damaged or disconnected

Contact the developer

Pressure sensor calibration error

Sensor goes wrong during maintenance

Contact the developer

12

12

12

12

12

0

11

11

10 Troubleshooting

Error Code

Level

A1030

11

Error Message

Probable Causes

Corrective Actions

Instruction execution is timed out

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

No response, or response error

Instruction error

Switch off analyzing unit power and switch on again. Restore failure on Utilities-->Daily Maint. page. If this message appears for 3 times, contact the developer

Diluted wash solution B is not enough

Valve goes wrong. No diluted wash solution. Distilled water is not enough. Liquid-level sensor goes wrong

Troubleshoot failed part. Execute "System Prime" and select "Diluted Wash Solution Tank Prime"

Concentrat ed wash solution B is not enough

Valve goes wrong. No concentrated wash solution. Distilled water is not enough. Liquid-level sensor goes wrong

Troubleshoot failed part. Execute "System Prime" and select "Concentrated Wash Solution Refill"

High-conce ntration waste bucket is too high

High-concentration waste is full, or high-concentration waste bucket sensor goes wrong

Shut down the analyzer. Check and empty the high-concentration waste tank. If error remains, contact the developer

Vacuum container is too high

Liquid builds up in vacuum container

Shut down the analyzer. Empty the vacuum tank. If error remains, contact the developer

Pressure of 25psig gauge is less than 1psig

Air pump is blocked and cannot work

Turn off air pump and turn on again. If the error remains, shut down the analyzer

Pressure of 25psig gauge is less than 20psig in standby status

Tubing are leaking or not connected properly

Shut down the analyzer and check the fluidic tubing connection

Execution result is not received in given time

A1031

11

A1032

10

A1033

0

A1034

0

A1035

12

A1036

A1037

12

12

10 Troubleshooting

execute

10-43

Error Code

Level

Error Message

A1038

12

Pressure of 25psign gauge is within 27-35psig

A1039

A1040

A1041

A1042

A1043

12

12

12

12

Corrective Actions

Protection valve is not adjusted correctly

Adjust the protection valve to increase pressure to 25psig(0.172MPa)

Pressure of 25psign gauge is greater than 35psig at any time

Protection valve and one-way valve are blocked. Tubing is clogged or broken

Shut down the analyzer, clean the tubing, check the protection valve, pressure switch, power supply and power cord. Then start up the analyzer

Vacuum pressure is greater than -0.5psig

Air pump is blocked and cannot work

Turn off air pump and turn on again. If the error remains, shut down the analyzer

Vacuum pressure is greater than -10psig in standby status

Tubing are leaking or not connected properly

Shut down the analyzer and check the fluidic tubing connection

Pressure of 10psig gauge is less than 1psig

Air pump is blocked and cannot work

Turn off air pump and turn on again. If the error remains, shut down the analyzer

Pressure of 10psig gauge is less than 8psig in standby status

Tubing are leaking or not connected properly

Shut down the analyzer and check the fluidic tubing connection

A1044

12

Pressure of 10psign gauge is greater than 13psig

Inlet valve cannot be turned off. Water tank overflow. Pressure too high

Shut down the analyzer, check the water supply and floater of water tank. Replace the inlet valve if necessary

A1045

12

Pressure of 5psig gauge is less than 1psig

Air pump is blocked and cannot work

Turn off air pump and turn on again. If the error remains, shut down the analyzer

Pressure of 5psig gauge is less than 3psig in standby status

Tubing are leaking or not connected properly

Shut down the analyzer and check the fluidic tubing connection

A1046

10-44

12

Probable Causes

12

10 Troubleshooting

Error Code

Level

Error Message

A1047

12

A1048

A1049

A1050

A1051

A1052

12

12

12

12

12

Probable Causes

Corrective Actions

Result error: Diluted wash solution tank emptying failed

Not enough pressure

Contact the developer

Result error: System pressure releasing failed

Tubing clogged

Troubleshoot the tubing

Result error: System pressure establishin g failed

Tubing leaking

Troubleshoot the tubing

Result error: Diluted wash solution tank priming failed

Pressure cannot reach the expected value

Restart the vacuum and pressure gauges

Result error: System vacuum releasing failed

Tubing clogged

Troubleshoot the tubing

Result error: System vacuum establishin g failed

Tubing leaking

Troubleshoot the tubing

10.2.2.12 ISE Unit Error Code

Level

Error Message

Probable Causes

Corrective Actions

A1101

14

ISE unit handshake is abnormal

ISE unit connection error

Reconnect. Reset ISE unit. Power on ISE unit again

A1102

14

ISE unit is busy

ISE unit is executing other instruction

Wait a moment, and re-execute ISE instruction

10 Troubleshooting

10-45

Error Code

Level

A1103

14

A1104

A1105

A1106

A1107

10-46

Error Message

Probable Causes

Corrective Actions

ISE unit does not respond

Power switched off. Communication failed. Serial cable damaged or unconnected. Module connector damaged. Board elements damaged

Reconnect to power. Reconnect serial cable. Perform ISE initialization. Contact the developer to replace board

Na+ electrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or Na+ electrode and rerun. Monitor temperature, if too high, relocate equipment

K+ electrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or K+ electrode and rerun. Monitor temperature, if too high, relocate equipment

Clelectrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or Cl- electrode and rerun. Monitor temperature, if too high, relocate equipment

Li+ electrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or Li+ electrode and rerun. Monitor temperature, if too high,

14

14

14

14

10 Troubleshooting

Error Code

Level

Error Message

Probable Causes

Corrective Actions relocate equipment

A1108

A1109

A1110

A1111

A1112

A1113

A1114

A1115

A1116

14 Na+ electrode noise error

Electrode degenerated. Noise spike interference

Replace electrode and rerun. Check for electrical noise. If board element is damaged, replace the board

K+ electrode noise error

Electrode degenerated. Noise spike interference

Replace electrode and rerun. Check for electrical noise. If board element is damaged, replace the board

Clelectrode noise error

Electrode degenerated. Noise spike interference

Replace electrode and rerun. Check for electrical noise. If board element is damaged, replace the board

Li+ electrode noise error

Electrode degenerated. Noise spike interference

Replace electrode and rerun. Check for electrical noise. If board element is damaged, replace the board

Na+, K+, Cl-, Li+ electrodes noise error

Reference electrode degenerated. Environment interfered by electrical noise spike

Replace reference electrode and rerun. Check for electrical noise. Check unit grounding. If board element is damaged, replace the board

Na+ electrode drift

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

K+ electrode drift

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

Clelectrode drift

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

Li+ electrode drift

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15

14

14

14

14

14

14

14

14

10 Troubleshooting

10-47

Error Code

Level

Error Message

Probable Causes

Corrective Actions minutes and test again

A1117

A1118

A1119

A1120

A1121

A1122

A1123

A1124

14 Na+, K+, Cl-, Li+ electrodes drift

Reference electrode degenerated. Environmental electric pulse. New electrode or new calibrant A is used

Replace reference electrode and rerun. Check for electrical noise. If board element is damaged, replace the board. Check calibrant A channel and recalibrate

Na+ electrode voltage overflow

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

K+ electrode voltage overflow

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

Clelectrode voltage overflow

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

Li+ electrode voltage overflow

Electrode degenerated. New electrode or new calibrant A is used

Replace failed electrode and run. Check calibrant A channel and recalibrate. In case of new electrode, drift may occur, wait for 15 minutes and test again

Na+, K+, Cl-, Li+ electrodes voltage overflow

Reference electrode degenerated. Environmental electric pulse. New electrode or new calibrant A is used

Replace reference electrode and rerun. Check for electrical noise. If board element is damaged, replace the board. Check calibrator A channel and recalibrate

Air sample

Insufficient sample. Sample not aspirated to measurement chamber. Tubing aged. Pump tubing clogged or too long

If sample is less than 70µl, increase sample volume. Fill sufficient sample in tube. In case of wrong electrode installation, install again. Replace the tubing

Calibrant A depleted. Tubing unconnected. Calibrant A pump failure. Tubing clogged/cracked/bent. Fibrin and salt in electrode tubing. Bubble detector

Check spring/sealing ring. Ensure all electrodes/O rings are correct. Launch a wash procedure. Disassemble the unit and reinstall sensor. Replace bubble detector, waste pump, or calibrant A and

14

14

14

14

14

3 in

14 Air in calibrant A

10-48

10 Troubleshooting

Error Code

A1125

Level

Error Message

Corrective Actions

failure. Waste pump failure

recalibrate. Reconnect/replace tubing. Check electrical connection. Replace pump housing, motor, or tubing

14 Air in calibrant B. Fibrin and salt in electrode tubing. Bubble detector failure. Waste pump failure

In case of wrong electrode installation, check spring and sealing ring. Ensure all electrodes and O rings are installed correctly. Press Clean on water treatment system to wash. Disassemble this unit and wash and reinstall sensor. Replace bubble detector. Replace waste pump.

Air in calibrant B and A. Fibrin and salt in electrode tubing. Bubble detector failure. Waste pump failure

In case of wrong electrode installation, check spring and sealing ring. Ensure all electrodes and O rings are installed correctly. Press Clean on water treatment system to wash. Disassemble this unit and wash and reinstall sensor. Replace bubble detector. Replace waste pump.

No fluid in tubing

Calibrator A/B depleted. No sample or cleaning solution

Replace reagent package. Check the tubing

Air in calibrant B

A1126

Probable Causes

14

Air cleaner

in

A1127

14

A1128

14

Instruction execute error

Instruction format error, or parameter error

Please contact developer

A1129

14

Calibrations saving error

ISE unit cannot store calibration results

Recalibrate

A1130

14

Bubble detector failure

Bubble detector damaged

Replace detector

A1131

14 Calibration failed

Electrode slope is out of range during calibration

10 Troubleshooting

is

the

the

bubble

Calibrate repeatedly. If problem remains, reinstall failed electrode. If problem still remains, replace the electrode

10-49

Error Code

Level

A1132

14

Error Message

Probable Causes

Corrective Actions

Instruction format error. Parameter error. No execute condition

If maintaining, send instruction again, if testing, rerun. Otherwise restart operation unit and analyzing unit. If this problem remains, contact the developer

Instruction execution is timed out

Switch off analyzing unit power and switch on again. Reset mechanically on Utilities-->Alignment page. If this message appears for 3 times, contact the developer

No response, or response error

Instruction error

Switch off analyzing unit power and switch on again. Reset mechanically on Utilities-->Alignment page. If this message appears for 3 times, contact the developer

Na+ electrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or Na+ electrode and rerun. Monitor temperature, if too high, relocate equipment

K+ electrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or K+ electrode and rerun. Monitor temperature, if too high, relocate equipment

Instruction execute error

A1133

11 Execution result is not received in given time

A1134

A1135

A1136

10-50

11 execute

0

0

10 Troubleshooting

Error Code

Level

A1137

0

A1138

Error Message

Probable Causes

Corrective Actions

Clelectrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or Cl- electrode and rerun. Monitor temperature, if too high, relocate equipment

Li+ electrode slope is out of standard range

Electrode installation incorrect. Calibrator expired. Electrode degenerated. Bubbles in reference electrode. Reference electrode damaged. Electrodes interfered. Module or tubing temperature above 37

Reinstall sensor. Replace calibrant B and rerun, if still low, replace calibrant A and rerun. Replace failed sensor and rerun. Reinstall electrode, eliminate bubbles and calibrate. Replace reference or Li+ electrode and rerun. Monitor temperature, if too high, relocate equipment

0

10.2.2.13 Others Error Code

Level

Error Message

Probable Causes

Corrective Actions

A1401

11

Undefined failure

Generated error code is out of defined range

Upgrade the operating software, or contact the service engineer

10 Troubleshooting

10-51

11

Calculation Methods

11.1 Reaction Types The BS-400/BS-420 provides three reaction types for measurement: „ „ „

Endpoint Fixed-time Kinetic

11.1.1 Endpoint The endpoint or, more correctly, equilibrium method, is most ideal. The reaction reaches equilibrium after a period of time. Since the equilibrium constant is very large, it can be considered that all substrates (analytes) have changed into products, and absorbance of the reaction liquid does not change any more. The absorbance change is directly proportional to the analytes concentration. The endpoint reaction is largely insensitive to minor changes in such condition changes as amount of enzyme, pH value and temperature, provided the changes are not significant enough to affect the reaction time.

11 Calculation Methods

11-1

11.1.1.1 Single-reagent Figure 11-1 Single-reagent Endpoint Reaction Curve

As shown in Figure 11-1, R1 is the time when reagent is dispensed and S when sample is dispensed. From L to M the reaction reaches equilibrium and the absorbance reading is taken. The reagent blank is tested during N and P.

„

On the Basics window of the Test page, enter: Reaction time: L and 14≤L≤M≤80 and M-4≤L M Reagent blank time: N and P

„

1≤N≤P