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Name of

Illustration

Definition

Remedy

Defect CAPPING

It is the term used, I. Polish dies properly. when

the

upper

or Investigate other

lower segment of the steels or other tablet

separates materials.

horizontally,

either II. Use flat punches.

partially or completely III. Make proper from the main body of setting of lower punch a tablet and comes off during ejection. as

a

cap,

ejection

during IV. Adjust sweep-off

from

the blade correctly to

tablet press, or during facilitate proper subsequent handling.

ejection. V. Reduce speed of turret (Increase dwell time).

LAMINATION

It is the separation of I. Modify mixing a tablet into two or process. Add more

distinct adsorbent or

horizontal layers.

absorbent. II. Use a less amount of lubricant or change the type of lubricant.

CHIPPING

It is defined as the I. Dry the granules breaking

of

tablet properly or increase

edges, while the tablet lubrication. leaves

the press or II. Moisten the

during

subsequent granules to plasticize.

handling and coating Add hygroscopic

CRACKING

operations.

substances.

Small, fine cracks

I. Reduce granule size.

observed on the upper

Add fines.

and lower central

II. Moisten the

surface of tablets, or

granules properly and

very rarely on the

add proper amount of

sidewall.

binder.

STICKING

III. Improve It refers to the tablet I. Dry the granules granulation. Add dry material adhering to properly. Make binders. the die wall. moisture analysis to IV. Compress at room determine limits. temperature. II. Increase or change lubricant. III. Reduce the amount of binder or use a different type of binder. IV. Modify granulation and compress under controlled humidity. V. Modify mixing process. Add an absorbent. VI. Optimize the amount of binder and granulation technique.

MOTTLING BRIDGING

It is the term used to This occurs the describe an when unequal coating fillsof incolour the distribution

lettering or with logolight on on a tablet, the tablet and is or dark spots standing typically by out in ancaused otherwise improper application uniform surface.

I. Use appropriate Increasing the colorants. plasticizer or II. Change content the solvent changing system, the Change plasticizer can binder,

the

decrease Reduce the incidence drying of bridging. temperature and Use a

of the solution, poor smaller particle size. design of the tablet III. Mix properly and embossing,

high reduce size if it is of a coating viscosity, high larger size to prevent percentage of solids in segregation. the

solution,

or IV. Incorporate dry improper atomization colour additive during pressure.

During

drying, the film may shrink and pull away from the sharp corners of an intagliation or bisect, resulting in a “bridging” surface.

of This

the defect

can be so severe that the bisect

monogram is

obscured.

or

completely

powder blending step, then

add

powdered such

fine

adhesives

as

acacia

and

and

mix

tragacanth

well and finally add granulating liquid. PRINT DEFECT

It is mainly observed Proper

tooling

in

good

tablets

which using

having

hard uniform

corners/designs

by and sized

on punches.

punches. It takes due to

improver

punch

cycle. Punches having rough

surface.

Improper blending of total

powder.

Letter

are

designed

with

uneven

surfaces

on

punches. ORANGE PEEL

It

is

surface

defect I. Use mild drying

resulting in the film conditions. being

rough

and II. Use additional

nonglossy.

solvents to decrease

Appearance is similar viscosity of solution. to that of an orange. TWINNING

Cracking/Splitting

This is the term for Assuming you don't two tablets that stick wish to change the together

and

it’s

a tablet shape, you can

common problem with solve this problem by capsule-shaped

balancing the pan

tablets.

speed and spray rate. Try reducing the spray rate or increasing the pan speed. In some cases, it is necessary to modify the design of the tooling by very slightly changing the radius. The change is

almost impossible to see, but it prevents the twinning problem.